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World Journal of Medicine (WJM) is an international journal of medical sciences and clinical practice, with intention to develop into the first dynamic international medical journal. It will not only offer up to date medical scientific and clinical practice information, but also facilitate international collaboration on medical research, education, and clinical practice.

Steroids may not be Immune to causing hepatotoxicity

 

Richa Uppal, MD1; Daryl Lau MD3; Tracy L. Challies, MD4, Amy Lin MD5; Wolfgang

Vogel MD6; Gerond Lake-Bakaar MD2,3

 

New York Downtown Hospital, New York, NY1; Center for the Study of Hepatitis C, Weill Cornell University Medical Center, New York, NY2. Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA3. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA4. Department of Medicine, Weill Cornell Medical Center, New York5. Division of Gastroenterology and Hepatology, Innsbruck Medical University, Austria6.

 

World J Med 2012; 7(4):301-6. Full Text (pdf)

 

 

 

 

 

Algorithms:

  • Endoscopic diagnosis of eosinophilic oesophagitis. WJM July 2020; Download
  • Clinical management of eosinophilic oesophagitis. WJM July 2020; Download

 

Chronic liver disease

Clinical reports, research progresses, end of life care, and other resources on chronic liver diseaseLearn more

Abstract

We report three cases of hepatocellular injury secondary to exposure to methylprednisolone. The first two patients were seen in the United States and the third in Austria. The pattern in all three cases suggests immune-mediated hypersensitivity reaction. The second and third patients fit the criteria for autoimmune–like, drug induced liver injury (AIH-DILI). One patient had a rechallengewith oral methylprednisolone to exclude excipients in the intravenous formulation as a cause of drug induced injury. The differences between AIH and AIH-DILI as well as evidence for rechallenge with a potentially harmful drug were also examined. The data strongly suggest that steroids can be associated with liver damage. In

with worsening liver function during therapy with steroids, these drugs should be considered as potential culprits.

Keywords: steroids, hepatotoxicity, hepatitis, HLA typing, rechallenge

Cited this article as: Uppal R et al: Steroids may not be immune to causing hepatotoxicity. World J Med 2012; 7(4):301-6.

 

 

Editorial:

Improving clinical diagnosis and management of eosinophilic oesophagitis in adult patients. World J Med 2020; Full text

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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