Home     Contact      Login    Register   Search  

  

Subscribe
 
Content Search

 

 

NCEPOD

Confidential clinical surveys and research on important issues of patient care

Steroids may not be Immune to causing hepatotoxicity

 

Richa Uppal, MD1; Daryl Lau MD3; Tracy L. Challies, MD4, Amy Lin MD5; Wolfgang

Vogel MD6; Gerond Lake-Bakaar MD2,3

 

New York Downtown Hospital, New York, NY1; Center for the Study of Hepatitis C, Weill Cornell University Medical Center, New York, NY2. Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA3. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA4. Department of Medicine, Weill Cornell Medical Center, New York5. Division of Gastroenterology and Hepatology, Innsbruck Medical University, Austria6.

 

World J Med 2012; 7(4):301-6. Full Text (pdf)

 

 

 

Chronic liver disease

Clinical reports, research progresses, end of life care, and other resources on chronic liver disease

Learn more

Abstract

We report three cases of hepatocellular injury secondary to exposure to methylprednisolone. The first two patients were seen in the United States and the third in Austria. The pattern in all three cases suggests immune-mediated hypersensitivity reaction. The second and third patients fit the criteria for autoimmune–like, drug induced liver injury (AIH-DILI). One patient had a rechallengewith oral methylprednisolone to exclude excipients in the intravenous formulation as a cause of drug induced injury. The differences between AIH and AIH-DILI as well as evidence for rechallenge with a potentially harmful drug were also examined. The data strongly suggest that steroids can be associated with liver damage. In patients with worsening liver function during therapy with steroids, these drugs should be considered as potential culprits.

Keywords: steroids, hepatotoxicity, hepatitis, HLA typing, rechallenge

Cited this article as: Uppal R et al: Steroids may not be immune to causing hepatotoxicity. World J Med 2012; 7(4):301-6.

 

 

 

User
Online submission
  • Notifications
  • Information