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NCEPOD

Confidential clinical surveys and research on important issues of patient care

World Journal of Medicine (WJM) is an international journal of medical sciences and clinical practice, with intention to develop into the first dynamic international medical journal. It will not only offer up to date medical scientific and clinical practice information, but also facilitate international collaboration on medical research, education, and clinical practice.

 

Chronic liver disease

Clinical reports, research progresses, end of life care, and other resources on chronic liver disease.

 

endoscopy

Preparation & pre-assessment, endoscopy room guidelines, endoscopy training, and other resources on the Endoscopy

 

Medical News

Archives

Original Articles

Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial Prof Janusz A Z Jankowski, The Lancet: July 26, 2018

High-dose PPI and aspirin chemoprevention therapy, especially in combination, significantly and safely improved outcomes in patients with Barrett's oesophagus.

Procalcitonin in the Treatment of Acute Respirotary Illness D.T. Huang, NEJM 2018

Differentiating acute bacterial infection from other causes of lower respiratory tract illness is challenging. In this trial, procalcitonin was investigated as a point-of-care test to aid in determining whether antibiotics were needed in the treatment of these illnesses.

 

Neurophysiological signatures of Alzheimer’s disease and frontotemporal lobar degeneration: pathology versus phenotype Saber Sami; Brain, August 2018

The authors identify characteristic neurophysiological signatures of five neurodegenerative diseases, including two variants of Alzheimer’s disease and three forms of frontotemporal lobar degeneration. Disorders that share a common underlying pathology have a similar spectral signature of altered connectivity, regardless of phenotype.

Dengue Vaccination S. Sridhar et al. ENJM 2018

Concerns have been raised about the risk of severe dengue in children who were seronegative before receipt of a recently deployed dengue vaccine. In this study, data from field trials were analyzed to assess the effect of baseline serostatus on subsequent severe illness.

Reviews

Mitochondrial Quality Control in COPD and IPF Hiromichi Hara; Cell: July 2018

Interactive Case

A Lump in the Neck  M.C. Honigberg, et al.

This interactive case features a 44-year-old man with known HIV infection who presents with a large mass on the side of his neck. Test your diagnostic and therapeutic skills.

 

Technical Report

New modified hook device for endoloop closure of the mucosal defect after gastric endoscopic submucosal dissection Tatsuma Nomura, Endoscopy 2018.

 

 

D-dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events and Cancer in Stable Coronary Heart Disease Patients: The LIPID Study John Simes, et al. Circulation 2018.

D-dimer levels predict long-term risk of arterial and venous events, CVD mortality, and non-CVD noncancer mortality, independently of other risk factors. D-dimer is also a significant predictor of cancer incidence and mortality. These results support an association of D-dimer with fatal events across multiple diseases and demonstrate that this link extends beyond 10 years' follow-up.

Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011-15: observational study Scott W Olesen;BMJ 2018; July 2018

Among US Medicare beneficiaries, overall antibiotic use and potentially inappropriate use in 2011-15 remained steady or fell modestly, but individual drugs had divergent changes in use. Trends in drug use across indications were stronger than trends in use for individual indications, suggesting that guidelines and concerns about antibiotic resistance were not major drivers of change in antibiotic use.

Geographic Variability in Liver Disease-Related Mortality Rates in the United States  Archita P. AJM: July 2018.

There is significant interstate variability in liver disease mortality rates, with the South and Midwest carrying the highest rates of liver disease mortality. There is significant association between a state’s liver disease mortality rate and higher proportion of Hispanic population, racial diversity, and household income.

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